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| Catalog Code: | NB100-77836 |
| Product Name: | CD184 Antibody |
| Product Description: | Mouse Monoclonal anti-CD184 (12G5), conjugated to Biotin |
| Clone: | 12G5 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Cross Reactivity: | Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD184, also known as fusin or CXCR4, is a 45 kD seven transmembrane G-protein-linked CXC chemokine receptor. CD184 is widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, lymphoid, myeloid precursor cells, endothelial cells, epithelial cells, astrocytes, and neurons, among other tissue cells. CD184 is the receptor for CXC chemokine SDF-1, mediates blood cell migration, and is involved in B lympho- and myelopoiesis, cardiogenesis, blood vessel formation and cerebellar development. CXCR4 is also a coreceptor of X4 HIV-1 and an alternative receptor for some isolates of HIV-2. The 12G5 antibody has been reported to block CD4-independent infection by HIV-2 and CD4-dependent infection by some T cell-tropic isolates of HIV-1. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu, Bb, Mk |
| Alternate Names: | anti-CXCR4 antibody, anti-Fusin CXCR 4 antibody, anti-CXCR-4 antibody |
| Package Size: | 0.1 mg |
| Conjugate: | Biotin |
| General References: | 1. Berger, E., et al., 1999. Annu. Rev. Immunol. 17:657. 2. Loetscher, P., et al., 2000. Adv. Immunol. 74:127. 3. Murphy, P., et al., 2000. Pharmacol. Rev. 52:145 |
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