| CatalogCode: | NB100-77816 |
| ProductName: | CD86 Antibody |
| Product Description: | Mouse Monoclonal anti-CD86 (IT2.2), conjugated to Biotin |
| Clone: | IT2.2 |
| Clonality: | Monoclonal |
| CrossReactivity: | Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.25 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Monocytes/macrophages, activated B and T cells, dendritic cells |
| Background: | CD86 is an 80 kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, monocytes/macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, known as CTLA-4, to deliver an inhibitory signal to T cells. The IT2.2 antibody blocks T cell activation. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host_Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu, Bb, Mk |
| ALTnames: | anti-B7-2 antibody, anti-B7 2 antibody, anti-B70 antibody |
| ProteinTarget: | CD86 |
| PackageSize: | 0.1 mg |
| Conjugate: | Biotin |
| GeneralRef: | 1. Hathcock, K., et al., 1996. Adv. Immunol. 62:131. 2. June, C., et al., 1994 |
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