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| Catalog Code: | NB100-77708 |
| Product Name: | CD106 Antibody |
| Product Description: | Mouse Monoclonal anti-CD106 (MR106), conjugated to Biotin |
| Clone: | MR106 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Rat VCAM-1 transfected L5178Y cells |
| Cross Reactivity: | Rat. |
| Packaging: | 0.5 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD106 is a 110 kD transmembrane protein also known as VCAM-1 and INCAM-110. It is an immunoglobulin superfamily member and is expressed on bone marrow stromal cells, myeloid cells, splenic dendritic cells and endothelial cells (activated by cytokines). CD106 is a counter-receptor for VLA-4 ( alpha4 beta1 integrin) and LPAM-1 ( alpha4 beta7 integrin). The interactions of CD106 and VLA-4 or LPAM-1 play an important role in binding of leukocytes to activated endothelial cells and leukocyte extravasation at inflammatory sites. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Rt |
| Alternate Names: | anti-VCAM-1 antibody, anti-VCAM1 antibody, anti-INCAM-110 antibody, anti-INCAM110 antibody |
| Package Size: | 0.5 mg |
| Conjugate: | Biotin |
| General References: | 1. Barclay, A.N. et al., 1997. The Leukocyte Antigen FactsBook. Academic Press. 2. Kinashi, T., et al., 1995. J. Leuk. Biol. 57:168. 3. Bevilacquea, M.P. 1993. Ann. Rev. Immunol. 11:767. |
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