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| Catalog Code: | NB100-77683 |
| Product Name: | CD107a Antibody |
| Product Description: | Rat Monoclonal anti-CD107a (1D4B) |
| Clone: | 1D4B |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Mouse embryo 3T3 cells |
| Cross Reactivity: | Mouse. |
| Packaging: | 0.2 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. The mature CD107a is heavily glycosylated from a 40 kD core protein. It is expressed by macrophages, epithelial cells, endothelial cells, and some tumor cells. This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of lysosome membrane from lysosomal hydrolases. CD107a is a ligand for galaptin. Upon activation, CD107a is transferred to the surface of cell membrane. It plays a role in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis , immunofluorescence , immunoprecipitation , Immunohistochemistry-Frozen |
| Species Summary: | Mu |
| Alternate Names: | anti-Lysosome-Associated Membrane Protein 1 antibody, anti-LAMP-1 antibody anti-LAMP1 antibody, anti-LGP-120antibody |
| Package Size: | 0.2 mg |
| General References: | 1. Barclay, A.N., et al. 1997. The Leucocyte Antigen Facts Book. 2nd edition. Academic Press.2. Heffernan, M., et al. 1989. Cancer Res. 49: 6077.3. Granger, B. L., et al. 1990. J. Bio. Chem. 265: 12036. |
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