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| Catalog Code: | NB100-77646 |
| Product Name: | Tim-1 Antibody |
| Product Description: | Rat Monoclonal anti-Tim-1 (RMT1-4) |
| Clone: | RMT1-4 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Cross Reactivity: | Mouse. |
| Packaging: | 0.05 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance in each application. |
| Background: | Tim-1 is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-1 and hepatitis virus cellular receptor 1. It is developmentally expressed at high levels in the blastocyst. Tim-1 is expressed on activated CD4+ lymphocytes especially on Th2 cells and has been implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-1 is hepatitis A virus receptor in humans. Tim-4 is the endogenous ligand of Tim-1. The interaction of Tim-1 and Tim-4 is involved in costimulation of T cell proliferation. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | anti-Tim1 antibody, anti-T Cell immunoglobulin and mucin domain protein 1 antibody, anti-T Cell Tapr antibody |
| Package Size: | 0.05 mg |
| General References: | 1. McIntire, J. J., et al., 2001. Nature Immunol. 2:1109.2. Kuchroo, V.K., et al., 2003. Nat. Rev. Immunol. 3:454.3. Wills-Karp, M., et al., 2001. Nat. Rev. Immunol. 1:69. |
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