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| Catalog Code: | NB100-77511 |
| Product Name: | ICOS Antibody |
| Product Description: | Hamster Monoclonal anti-ICOS (15F9) |
| Clone: | 15F9 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Cross Reactivity: | Mouse. |
| Packaging: | 0.5 mg Immunogen affinity purified Hamster antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD278 is a 47-57 kD protein, also known as inducible costimulatory molecule (ICOS), or H4. This protein is homologous to the CD28/CTLA-4 proteins. It forms homodimers and is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. It has also been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Hamster |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis , Immunohistochemistry-Frozen |
| Species Summary: | Mu |
| Alternate Names: | anti-Inducible COStimulator molecule antibody, anti-H4 antibody, anti-CD278 antibody |
| Package Size: | 0.5 mg |
| General References: | 1. Rudd, C.E., et al., 2003. Nat. Rev. Immunol. 3:54 |
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