| CatalogCode: | NB100-77504 |
| ProductName: | B7-RP1 Antibody |
| Product Description: | Rat Monoclonal anti-B7-RP1 (HK5.3), conjugated to Biotin |
| Clone: | HK5.3 |
| Clonality: | Monoclonal |
| Immunogen: | Mouse B7-RP1 transfected cell line |
| CrossReactivity: | Mouse. |
| Packaging: | 0.05 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Two isoforms produced by alternative splicing. Isoform 1 expressed in spleen (marginal zone), lymph |
| Background: | B7-RP1 is a 40 kD protein, also known as ICOS ligand, B7-H2, and B7h. It has recently been clustered as CD275. It is a member of the immunoglobulin receptor superfamily expressed on splenic B cells, dendritic cells and macrophages. The expression of this antigen is increased by TNF- alpha stimulation and is highly upregulated by local inflammation. B7RP1 binds to ICOS and co-stimulates T cell and B cell responses. Two isoforms of this protein have been reported to occur as a result of alternative splicing. These isoforms show differential tissue distribution. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host_Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| ListPrice: | 180 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | anti-PD-L2 antibody, anti-PDL2 antibody, anti-B7DC antibody, anti-CD273 antibody |
| ProteinTarget: | B7-RP1 |
| PackageSize: | 0.05 mg |
| Conjugate: | Biotin |
| GeneralRef: | 1. Yoshinaga, S. K., et al. 1999. Nature 402:827.2. Ling, V., et al. 2000. J. Immunol. 164:1653.3. Ling, V., et al., 2001. J. Immunol. 164:1653. |
order or
more information: | company product webpage |
| request information: |
|