| CatalogCode: | NB100-77487 |
| ProductName: | CD152 Antibody |
| Product Description: | Hamster Monoclonal anti-CD152 (UC10-4B9) |
| Clone: | UC10-4B9 |
| Clonality: | Monoclonal |
| Immunogen: | Mouse CTLA-4-mouse IgG2a fusion protein |
| CrossReactivity: | Mouse. |
| Packaging: | 0.5 mg Immunogen affinity purified Hamster antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Activated T and B cells |
| Background: | CD152 is a 33 kD member of the immunoglobulin superfamily also known as CTLA-4 or Ly-56. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance, as well as the development of protective immunity and thymocyte regulation. The UC10-4B9 antibody can enhance T cell co-stimulation by blocking CTLA-4 interactions with the B7 co-receptors, favoring CD28 interactions. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Hamster |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| ListPrice: | 285 |
| AppSummary: | ELISA, FACS, IP |
| SpeciesSummary: | Mu |
| ALTnames: | anti-Cytotoxic T Lymphocyte-Associated Antigen 4 antibody, anti-CTLA-4 antibody, anti-Ly56 antibody, anti-Ly-56 antibody, anti-CTLA4 antibody |
| ProteinTarget: | CD152 |
| PackageSize: | 0.5 mg |
| GeneralRef: | 1. Barclay, A., et al., 1997. The Leukocyte Antigen FactsBook, Academic Press. 2. Allison, J.P., et al., 1995. Science 270:932. 3. Waterhouse, P., et al., 1995. Science 270:985. |
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