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| Catalog Code: | NB100-77474 |
| Product Name: | CD106 Antibody |
| Product Description: | Rat Monoclonal anti-CD106 (429) |
| Clone: | 429 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Mouse preadipose cell line PA6 |
| Cross Reactivity: | Mouse. |
| Packaging: | 0.5 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.25 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD106 is a 110 kD glycosylphosphatidylinositol (GPI)-linked transmembrane protein, also known as VCAM-1 and INCAM-110. It is constitutively expressed on bone marrow stromal cells, myeloid progenitors, splenic dendritic cells, activated endothelial cells, as well as some lymphocytes. CD106 expression can be upregulated on endothelial cells by inflammatory cytokines. CD106 is involved in adhesion and acts as a counter-receptor for VLA-4 ( alpha4/ beta1 integrin) and LPAM-1 ( alpha4/ beta7 integrin). The 429 antibody has been reported to partially block VCAM-1-mediated binding. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis , immunoprecipitation , Immunohistochemistry-Frozen |
| Species Summary: | Mu |
| Alternate Names: | anti-VCAM1 antibody, anti-VCAM-1 antibody, anti-INCAM110 antibody, anti-INCAM-110 antibody |
| Package Size: | 0.5 mg |
| General References: | 1. Barclay, A.N. et al., 1997. The Leukocyte Antigen FactsBook, Academic Press. 2. Kinashi, T., et al., 1995. J. Leukoc. Biol. 57:168. 3. Bevilacquea, M.P. 1993. Annu. Rev. Immunol. 11:767. |
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