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| Catalog Code: | NB100-77468 |
| Product Name: | CD94 Antibody |
| Product Description: | Rat Monoclonal anti-CD94 (18d3) |
| Clone: | 18d3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | CHO cells expressing the B6 alleles of CD94 and NKG2A |
| Cross Reactivity: | Mouse. |
| Packaging: | 0.5 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.25 microgram per one million cells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD94 is a 43/39 kD C-type lectin, also known as Kp43. It is present on all NK cells, NK-T cells, and a subset of CD8-positive T lymphocytes in most mouse strains. CD94 is a type-II transmembrane protein with an extracellular lectin-like domain and a short cytoplasmic tail. CD94 is expressed as a disulphide-linked heterodimer with a NKG2 subunit believed to mediate signal transduction. When associated with NKG2A, the complex triggers inhibition; when associated with NKG2C, the complex triggers stimulation. The receptor complex of CD94 and NKG2 receptors bind to the ligand, Qa-1, and are thought to play a role in maintaining self-tolerance in developing NK cells. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | anti-Kp43 antibody |
| Package Size: | 0.5 mg |
| General References: | 1. Barclay, A., et al., 1997. The Leukocyte Antigen FactsBook, Academic Press. 2. Lopez-Botet, M., et al., 1997. Immunol. Rev. 155:165. 3. Moretta, A., et al., 1997. Immunol. Rev. 155:105. |
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