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| Catalog Code: | NB100-77370 |
| Product Name: | CD11a Antibody |
| Product Description: | Rat Monoclonal anti-CD11a (M17/4) |
| Clone: | M17/4 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | C57BL/6 mouse splenic secondary cytotoxic T cells |
| Cross Reactivity: | Mouse. |
| Packaging: | 0.5 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.25 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD11a is a 180 kD glycoprotein, also known as alphaL integrin, LFA-1 alpha, Ly-15, or Ly-21. It is a member of the integrin family, primarily expressed on lymphocytes, monocytes/macrophages, and granulocytes. In association with CD18, the CD11a/CD18 complex forms LFA-1. CD11a plays an important role in intercellular adhesion and costimulation by binding its ligands, ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50). The M17/4 antibody can block CD11a-mediated cellular adhesion. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis , immunoprecipitation , Immunohistochemistry-Frozen |
| Species Summary: | Mu |
| Alternate Names: | anti-alpha integrin antibody, anti-LFA1 antibody, anti-LFA-1 antibody, anti-Ly15 antibody, anti-Ly-15 antibody, anti-Ly21 antibody, anti-Ly-21 antibody |
| Package Size: | 0.5 mg |
| General References: | 1. Barclay, A., et al., 1997. The Leukocyte Antigen FactsBook, Academic Press. 2. Springer, T.A. 199 |
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