| CatalogCode: | | NB100-77340 |
| ProductName: | | PSCD2 Antibody |
| Product Description: | | Goat Polyclonal anti-ARNO / cytohesin 2 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide, EDGVYEPPDLTP-C, representing the N Terminus of the sequence according to NP_004219.2; NP_059431.1 |
| Epitope: | | EDGVYEPPDLTP |
| CrossReactivity: | | Human, rat. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 48kDa band observed in Human Brain (Cerebellum) and Rat Brain lysates (calculated MW of 46.5kDa according to NP_004219.2 and NP_059431.1). Recommended concentration: 0.5-1.5ug/ml. |
| Control: | | Human Brain (Cerebellum) lysate |
| Background: | | Pleckstrin homology, Sec7 and coiled/coil domains 2 (PSCD2) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. PSCD2 exhibits GEP activity in vitro with ARF1, ARF3, and ARF6. PSCD2 protein is 83% homologous to PSCD1. Two transcript variants encoding different isoforms have been found for this gene. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline [pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu, Rt |
| ALTnames: | | anti-pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) antibody, anti-ARNO antibody, anti-CTS18 antibody, anti-CTS18.1 antibody, anti-PSCD2L antibody, anti-SEC7L antibody, anti-Sec7p-L antibody, anti-Sec7p-like antibody, anti-ARF exchange factor antibody, anti-ARF nucleotide-binding site opener antibody, anti-cytohesin 2 antibody, anti-pleckstrin homology, Sec7 and coiled-coil domains 2-like antibody |
| ProteinTarget: | | ARNO / cytohesin 2 |
| PackageSize: | | 0.1 mg |
| Homology: | | Human, Mouse, Rat, Dog |
| GeneralRef: | | Kolanus W.Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transduction.Immunol Rev. 2007 Aug;218:102-13.PMID: 17624947 |
| NotesMain: | | This antibody is expected to recognise both reported isoforms (NP_004219.2; NP_059431.1). |
| Gene_Id: | | 9266 (human); 19158 (mouse); 116692 (rat); |
| Gene_Symbol: | | PSCD2 |
| Ref_Sqnce: | | NP_004219.2; NP_059431.1 |
| more information: | | company product webpage |
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