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| Catalog Code: | NB100-77324 |
| Product Name: | AKAP8L Antibody |
| Product Description: | Rabbit Polyclonal anti-HA95 |
| Clonality: | Polyclonal |
| ListPrice: | 375 |
| Gene ID: | 26993 |
| Reference Sequence: | NP_055186.2 |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 596 and 646 of human A kinase (PRKA) anchor protein 8-like (helicase A-binding protein 95 kDa) using the numbering given in entry NP_055186.2 (GeneID 26993). |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry on paraffin sections. Epitope exposure with citrate bufferexposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated. |
| Background: | AKAP8L/HA95 is a PKA anchoring protein that is localized to the nuclear envelope and associates with chromatin upon nuclear envelope breakdown during mitosis. AKAP8L/HA95 has been found to play an important role in the initiation of DNA replication and may function as a scaffold for proteins such as MCM2 and LAP2beta. Additionally, AKAP8L/HA95 has been shown to co-locate with the PKA C subunit in splicing factor compartments and is involved in the regulation of pre-mRNA splicing. Further support for a scaffolding and splicing role in the nucleus comes from the observation that AKAP8L/HA95 colocalizes with HypA, a splicing-like factor, and through this association may function as a docking site for the nuclear accumulation of Huntington protein as seen in Huntington's disease. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| Application Summary: | Immunohistochemistry-Paraffin 1:100-1:500 |
| Species Summary: | Hu |
| Alternate Names: | anti-AKAP8L antibody, anti-AKAP-8L antibody, anti-A kinase (PRKA) anchor protein 8-like antibody, anti-HA95 antibody, anti-HAP95 antibody, anti-helicase A-binding protein 95 kDa antibody, anti-NAKAP antibody, anti-NAKAP95 antibody, anti-neighbor of A kinase anchoring protein 95 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.09% sodium azide |
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more information: | company product webpage |