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| Catalog Code: | NB100-77316 |
| Product Name: | STUB1 Antibody |
| Product Description: | Rabbit Polyclonal anti-CHIP |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 10273 |
| Reference Sequence: | NP_005852.2 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 253 and 303 of human STIP1 homology and U-box containing protein 1 (carboxy terminus of Hsp70-interacting protein) using the numbering given in entry NP_005852.2 (GeneID 10273). |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunoprecipitation. It is not recommended for western analysis. |
| Background: | STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | immunoprecipitation 2-5 ug/mg lysate |
| Species Summary: | Hu |
| Alternate Names: | anti-STUB1 antibody, anti-STUB-1 antibody, anti-STIP1 homology and U-box containing protein 1 antibody, anti-CHIP antibody, anti-carboxy terminus of Hsp70-interacting protein antibody, anti-SDCCAG7 antibody, anti-serologically defined colon cancer antigen 7 antibody, anti-HSPABP2 antibody, anti-heat shock protein A binding protein antibody, anti-UBOX1 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% sodium azide |
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more information: | company product webpage |