| CatalogCode: | NB100-77315 |
| ProductName: | STUB1 Antibody |
| Product Description: | Rabbit Polyclonal anti-CHIP |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 1 and 50 of human STIP1 homology and U-box containing protein 1 (carboxy terminus of Hsp70-interacting protein) using the numbering given in entry NP_005852.2 (GeneID 10273). |
| CrossReactivity: | Human, Mouse. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for western blot and immunoprecitation. |
| Background: | STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| ListPrice: | 325 |
| AppSummary: | WB, IP |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-STUB1 antibody, anti-STUB-1 antibody, anti-STIP1 homology and U-box containing protein 1 antibody, anti-CHIP antibody, anti-carboxy terminus of Hsp70-interacting protein antibody, anti-SDCCAG7 antibody, anti-serologically defined colon cancer antigen 7 antibody, anti-HSPABP2 antibody, anti-heat shock protein A binding protein antibody, anti-UBOX1 antibody |
| ProteinTarget: | STUB1 |
| PackageSize: | 0.1 ml |
| Gene_Id: | 10273 |
| Ref_Sqnce: | NP_005852.2 |