| CatalogCode: | NB100-773 |
| ProductName: | SOCS3 Antibody |
| Product Description: | Goat Polyclonal anti-SOCS3 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide sequence PIREFLDQYDAPL representing the c-terminus (residues 213-225) of the human protein according to NP_003946. |
| CrossReactivity: | Cross-reacts with Human. Expected to cross-react with Rat and Mouse due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for Western Blot, where a 24kDa band is seen in MOLT-4 lysate. Recommended starting dilution*:Western Blot: 4.0-6.0ug/ml Optimal dilutions should be determined by the researcher. |
| Control: | MOLT-4 lysate |
| Background: | Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1 - 7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo, in response to cytokines. Once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad spectrum of cytokines, e.g. IL2, IL3, IL4, IL6, Epo, Prolactin, and GH. Recent findings suggest that aberrant induction of SOCS3 by pathogens, such as Leishmania donovani and hepatitis C virus, might interfere with the host immune response and contribute to the persistent infection by these pathogens. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CIS3 antibody, anti-Cish3 antibody, anti-Cytokine induced SH2 protein 3 antibody, anti-E2a Pbx1 target gene in fibroblasts 10 antibody, anti-EF 10 antibody, anti-SSI3 antibody, anti-STAT induced STAT inhibitor 3 antibody, anti-Suppressor of cytokine signaling 3 antibody |
| ProteinTarget: | SOCS 3 antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Roberts, A.W., et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. PNAS. 98(16):9324-9, 2001. |
| NotesMain: | LocusLink ID - 9021 (human); 12702 (mouse); 89829 (rat) |
| Gene_Id: | 9021 |
| Omim_ID: | H00009021-M02 |
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