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| Catalog Code: | NB100-77287 |
| Product Name: | PTPN11 Antibody |
| Product Description: | Rabbit Polyclonal anti-Shp2 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Gene ID: | 5781 |
| Reference Sequence: | NP_002825.3 |
| Concentration: | 1 mg/ml |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 543 and 593 of human tyrosine-protein phosphatase non-receptor type 11 using the numbering given in entry NP_002825.3 (GeneID 5781). |
| Cross Reactivity: | Human and Mouse. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for western blot and immunoprecitation. |
| Background: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate buffer, pH 7 to 8 |
| Application Summary: | Western Blot 1:2000-1:10000, immunoprecipitation 2-5 ug/mg lysate |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-PTPN11 antibody, anti-PTPN-11 antibody, anti-protein tyrosine phosphatase antibody, anti-non-receptor type 11 antibody, anti-NS1 antibody, anti-Noonan syndrome 1 antibody, anti-PTP2C antibody, anti-PTP-2C antibody, anti-Protein-tyrosine phosphatase 2C antibody, anti-SHPTP2 antibody, anti-Shp2 antibody, anti-SHP-2 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% sodium azide |
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more information: | company product webpage |