| CatalogCode: | NB100-768 |
| ProductName: | SEC61A1 Antibody |
| Product Description: | Goat Polyclonal anti-SEC61A1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide representing the C-terminus of the human protein (residues 463-476), according to NP_037468. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | This antibody can be used for Western Blot, where a 40 kDa band is seen in Daudi cell lysates. Not tested in any other application.Recommended Starting Dilution:*WB: 2-4 ug/ml*Optimal working dilutions should be determined by the investigator. |
| Background: | SEC61A1 belongs to the SECY/SEC61 alpha family. It has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum.The SEC61 complex is responsible for translocation of proteins across the rough endoplasmic reticulum membrane. SEC61 is composed of three subunits: alpha, beta, and gamma; that associate to form a heterotrimer. Multiple heterotrimers associate forming the ER translocon. SEC61 alpha is a polytopic protein that has ten membrane-spanning loops. SEC61 has been found to be tightly associated with membrane bound ribosomes, either directly or through adaptor proteins, and is required for assembly of membrane and secretory proteins. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris saline containing [pH7.3] with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-HSEC61 antibody, anti-protein transport protein SEC61 alpha subunit isoform 1 antibody, anti-Sec61 homolog antibody |
| ProteinTarget: | SEC61A1 antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Gorlich, D. et al. A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell 71:489-503 (1992). |
| Gene_Id: | 29927 |
| Omim_ID: | NB100-66316 |
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