| CatalogCode: | NB100-725SS |
| ProductName: | LYVE1 Antibody |
| Product Description: | Rabbit Polyclonal anti-LYVE1 **Sample Size** |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide made to a C-terminal portion of the murine LYVE-1 protein sequence (between residues 250-318). |
| CrossReactivity: | This antibody cross-reacts with mouse. It does not cross-react with human in Western blot. No other species have been tested. |
| Packaging: | 0.025 ml Rabbit antisera. |
| Uses: | Western blot where a band at ~45 kDa is seen and Immunohiostchemistry. For Immunohistochemistry citrate buffer antigen retrieval is recommended. No other applications have been tested. |
| Localization: | Plasma membrane |
| Control: | Mouse spleen lysate |
| Background: | The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, and podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module, the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Host_Name: | Rabbit |
| Buffer: | Tris-glycine, 150 mM NaCl, 0.05% NaN3 |
| ListPrice: | 100 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Mu |
| ALTnames: | anti-Extracellular link domain containing 1 antibody, anti-HAR antibody, anti-hyaluronic acid receptor antibody, anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody, anti-LYVE-1 antibody, anti-XLKD1 antibody |
| PackageSize: | 0.025 ml |
| GeneralRef: | 1. Laakkonen, P, et al. A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat. Med. 8(7):751-755 (2002). 2. Banerji, S., et al. LYVE-1, a new homologue of the CD44 Glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 144(4):789-801, 1999. 3. Prevo, R., et al. Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium. J. Biol. Chem. 276(22): 19420-19430, 2001. 4. Petrova, T.V., et al. Defective values and abnormal mural cell recruitment underlie lymphatic vascular faliure in lymphedema distichiasis. Nature Medicine. 10(9): 974-981, 2004. 5. Prevko, R., et al. Rapid plasma membrane-endosomal trafficking of the lymph node sinus and high endothelial venule scavenger receptor/homing receptor stabilin-1 (Feel-1/Clever-1). J. Biol. Chem. 279(50):52580-52592, 2004. |
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