| CatalogCode: | NB100-711 |
| ProductName: | CCR 8 Antibody |
| Product Description: | Goat Polyclonal anti-CCR 8 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: VTDYYYPDIFSSPCDAELIQTNGKLC, corresponding to amino acids 12-36 of Human CCR8. |
| Specificity: | Peptide sequence is < 50 % identical to other human chemokine receptors in this region. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | FACS: 1-3ul/10<sup>6</sup>/50-100ul. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Control: | Human K562 cells or tissue sections of spleen. |
| Background: | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation regulated cytokine (TARC) and macrophage inflammatory protein 1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. CCR* is also believed to be alternative coreceptor with CD4 for HIV-1 infection. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | PBS, 1mg/ml BSA, pH7.2 |
| ListPrice: | 285 |
| AppSummary: | FACS, ELISA, IHC-P, WB, ICC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-C C chemokine receptor type 8 antibody, anti-C C CKR 8 antibody, anti-CC chemokine receptor 8 antibody, anti-CC chemokine receptor chemr1 antibody, anti-CC chemokine receptor type 8 antibody, anti-CC CKR 8 antibody, anti-CCR 8 antibody, anti-CCR8 protein antibody, anti-CDw198 antibody, anti-CDw198 antigen antibody, anti-Chemokine (C C motif) receptor 8 antibody, anti-Chemokine (C C) receptor 8 antibody, anti-Chemokine (C C) receptor like 2 antibody, anti-Chemokine (CC motif) receptor 8 antibody, anti-Chemokine (CC) receptor 8 antibody, anti-Chemokine (CC) receptor like 1 antibody, anti-Chemokine (CC) receptor like 2 antibody, anti-Chemokine C C motif receptor 8 antibody, anti-Chemokine C C receptor 8 antibody, anti-Chemokine CC motif receptor 8 antibody, anti-Chemokine CC receptor 8 antibody, anti-Chemokine receptor 8 antibody, anti-Chemokine receptor like 1 antibody, anti-CKR L1 antibody, anti-CKRL 1 antibody, anti-CKRL1 antibody, anti-CMKBR 8 antibody, anti-CMKBR L2 antibody, anti-CMKBR8 antibody, anti-CMKBRL 2 antibody, anti-CMKBRL2 antibody, anti-CY 6 antibody, anti-CY6 antibody, anti-GPR CY6 antibody, anti-GPRCY6 antibody, anti-MGC129966 antibody, anti-MGC129973 antibody, anti-TER 1 antibody, anti-TER1 antibody |
| ProteinTarget: | CCR 8 |
| PackageSize: | 0.1 mg |
| GeneralRef: | <b>This product has been used in:</b>Horuk R <i>et al.</i> The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. <i>J Biol Chem</i> <b>273</b>:386-91 (1998). <PUBMED:9417093>Samson M <i>et al.</i> Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. <i>Eur J Immunol</i> <b>26</b>:3021-8 (1996). <PUBMED:8977299> 3. Gombert, M., et al. CCL1-CCR8 interactions:an axis mediating the recruitment of T cells and Langerhands-type dendritric cells to sites of atopic skin inflammation. J. Immunol. 174(8):5082-5091, 2005. 4. Strasly, M., et al. CCL16 activates an angiogenic program in vascular endothelial cells. Blood. 103(1): 40-49, 2004. 5. Haque, N.S., et al. CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoportein(a)-stimulated endothelial cell conditioned medium. Blood. 97(1): 39-45, 2001. |
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