| CatalogCode: | NB100-706 |
| ProductName: | CCR 10 Antibody |
| Product Description: | Goat Polyclonal anti-CCR 10 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: KPTEQVSWGLYSGYDEEAYSVGPLPELC, corresponding to amino acids 4-31 of Mouse CCR10. |
| Specificity: | Peptide sequence is < 50 % identical to other mouse chemokine receptors in this region. |
| CrossReactivity: | Cross-reacts with Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | ELISA: Use at a dilution of 1/100,000. ICC: Use at a dilution of 1/500. IHC: Use at a dilution of 1/250. WB: Use at a dilution of 1/1000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Control: | Mouse lymph nodes or small intestine. |
| Background: | Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 which displays chemotactic activity for resting CD4+ and CD8+ T cells. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2 |
| ListPrice: | 285 |
| AppSummary: | ELISA, IHC, WB, ICC |
| SpeciesSummary: | Mu |
| ProteinTarget: | CCR 10 |
| PackageSize: | 0.1 mg |
| GeneralRef: | <b>This product has been used in:</b>Zaballos A <i>et al.</i> Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. <i>J Immunol</i> <b>162</b>:5671-5 (1999). <PUBMED:10229797> 2. Wang, W., et al. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275:22313-22323, 2000. 3. Murakami, T., et al. Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J. Exp. Med. 198(9):1337-1347, 2003. |
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