| CatalogCode: | | NB100-68276 |
| ProductName: | | XPF/ERCC4 Antibody |
| Product Description: | | Rabbit Polyclonal anti-XPF/ERCC4 |
| Clonality: | | Polyclonal |
| Immunogen: | | The epitope recognized by this antibody maps to a region between residue 855 and 905 of human xeroderma pigmentosum, complementation group F using the numbering given in entry AAB07689.1 (GeneID 2072). |
| CrossReactivity: | | Human. |
| Packaging: | | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | | This antibody is useful for Immunohistochemistry on paraffin sections. Epitope exposure with citrate bufferexposure is recommended. Epitope exposure with citrate buffer will enhance staining. Likely to work with frozen sections. In some cases, the antibody may be diluted further than indicated. |
| Background: | | XPF/ERCC4 is suggested to play a role in the repair of DNA double-strand breaks (DSB), homologous recombination, and gene conversion via single-strand annealing (SSA). XPF/ERCC4 is an endonuclease that incises 5-prime DNA. Defects in XPF/ERCC4 cause xeroderma pigmentosum VI (XP6) an autosomal recessive disease characterized by hypersensitivity to sunlight and a predisposition to skin cancer as well as neurological abnormalities. Defects in XPF/ERCC4 are also responsible for XFE progeroid syndrome, a syndrome characterized by dwarfism, cachexia, and microcephaly. |
| Storage: | | Store at 4C. Do not freeze. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | Tris-buffered Saline containing 0.1% BSA |
| ListPrice: | | 375 |
| AppSummary: | | IHC-P |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-XPF antibody, anti-xeroderma pigmentosum antibody, anti-complementation group F antibody, anti-ERCC4 antibody, anti-ERCC-4 antibody, anti-excision repair cross-complementing rodent repair deficiency antibody, anti-complementation group 4 antibody, anti-RAD1 antibody |
| ProteinTarget: | | XPF/ERCC4 |
| PackageSize: | | 0.1 ml |
| Gene_Id: | | 2072 |
| Ref_Sqnce: | | AAB07689.1 |
| more information: | | company product webpage |