| CatalogCode: | NB100-68248 |
| ProductName: | TAB182 Antibody |
| Product Description: | Rabbit Polyclonal anti-TAB182 |
| Clonality: | Polyclonal |
| Immunogen: | The epitope recognized by this antibody maps to a region between residue 350 and 400 of human tankyrase 1-binding protein of 182 kDa using the numbering given in entry NP_203754.2 (GeneID 85456). |
| CrossReactivity: | Human. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for western blot and immunoprecipitation. |
| Background: | TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Tris-buffered Saline containing 0.1% BSA |
| ListPrice: | 325 |
| AppSummary: | WB, IP |
| SpeciesSummary: | Hu |
| ALTnames: | anti-TAB182 antibody, anti-tankyrase 1-binding protein of 182 kDa antibody, anti-TNKS1BP1 antibody, anti-tankyrase 1 binding protein 1 antibody |
| ProteinTarget: | TAB182 |
| PackageSize: | 0.02 mg |
| Gene_Id: | 85456 |
| Ref_Sqnce: | NP_203754.2 |