| CatalogCode: | | NB100-68144 |
| ProductName: | | OGG1 Antibody |
| Product Description: | | Goat Polyclonal anti-OGG1 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide, C-DLRQSRHAQEPPAK, representing the C Terminus of the sequence according to NP_002533.1; NP_058212.1 ; NP_058213.1; NP_058214.1; NP_058434.1; NP_058436.1; NP_058437.1; NP_058438.1 |
| Epitope: | | DLRQSRHAQEPPAK |
| CrossReactivity: | | Human. Other species not tested. |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | Peptide ELISA: antibody detection limit dilution 1:32,000. Western Blot: Approx 38kDa band observed in Human Brain (Cerebellum) lysates (calculated MW of 38.8kDa according to NP_002533.1). Recommended concentration: 0.2-0.6ug/ml. |
| Control: | | Human Brain (Cerebellum) lysate |
| Background: | | This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targetting signal, essential for mitochondrial localization. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline [pH7.3] with 0.5% BSA |
| ListPrice: | | 295 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-8-oxoguanine DNA glycosylase antibody, anti-HMMH antibody, anti-HOGG1 antibody, anti-MUTM antibody, anti-OGH1 antibody, anti-8-hydroxyguanine DNA glycosylase antibody, anti-OGG1 type 1d antibody, anti-OGG1 type 1e antibody, anti-OGG1 type 1g antibody, anti-OGG1 type 1h antibody |
| ProteinTarget: | | OGG1 |
| PackageSize: | | 0.1 mg |
| Homology: | | Human |
| GeneralRef: | | Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray CT.OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells.Nature. 2007 May 24;447(7143):447-52. Epub 2007 Apr 22.PMID: 17450122 |
| NotesMain: | | This antibody is expected to recognise isoform 1a (NP_002533.1) only. |
| Gene_Id: | | 4968 |
| Gene_Symbol: | | OGG1 |
| Ref_Sqnce: | | NP_002533.1; NP_058212.1 ; NP_058213.1; NP_058214.1; NP_058434.1; NP_058436.1; NP_058437.1; NP_05843 |
| more information: | | company product webpage |