| CatalogCode: | NB100-678 |
| ProductName: | ATM Antibody |
| Product Description: | Rabbit Polyclonal anti-ATM |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide (within amino acids 2550-2600), which represented a portion of human Ataxia Telangiectasia Mutated using the numbering given in SwissProt entry Q13315 (LocusLink ID 472). |
| Specificity: | This antibody is specific for human ATM. |
| CrossReactivity: | NB 100-678 recognizes human ATM. Other species have not been tested. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody can be used in Western blot and Immunoprecipitation. |
| Background: | Ataxia-telangiectasia (A-T) is a recessive childhood disease caused by mutations in the ATM (AT-mutated) gene. Symptoms include neurological abnormalities that cause unsteady posture, dilated blood vessels, infertility, radiation sensitivity, immune deficiencies and lymphoid malignancies. It appears that the diverse defects seen in ATM null mammals are manifestations of disparate signal transduction defects. The ATM protein is related to a family of proteins through a c-terminal phoshatidylinositol 3-kinase (PI3-kinase) domain. Members of the PI3-kinase family of proteins are involved in cell cycle control, DNA replication, recombination and repair. ATM also shares sequence homology with portions of the yeast RAD3 gene. The main role of ATM appears to be induction of a DNA-damage control pathway in response to genotoxic insults, such as ionizing radiation or anti-tumor medications and the programmed DNA breaks of meiosis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host_Name: | Rabbit |
| Buffer: | Tris-citrate/phosphate [pH7-8] containing 0.09% sodium azide |
| ListPrice: | 285 |
| AppSummary: | IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-AT complementation group A antibody, anti-AT complementation group C antibody, anti-AT complementation group D antibody, anti-AT complementation group E antibody, anti-AT mutated protein antibody, anti-AT1 antibody, anti-ATA antibody, anti-Ataxia telangiectasia gene mutated antibody |
| ProteinTarget: | ATM antibody |
| PackageSize: | 0.1 ml |
| NotesMain: | Blocking peptide is available or can be made for this item. Lead time is 3 days to 4 weeks. Price is $ 150/0.25 ml (or 50 ug). Please enquire availability. |