| CatalogCode: | NB100-66563 |
| ProductName: | Bak Antibody |
| Product Description: | Rabbit Polyclonal anti-Bak |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acids 14-36 of human Bak. |
| Specificity: | NB100-66563 recognises human Bak, a 24kD apoptosis related protein which is a member of the Bcl-2 family.This antibody shows no cross-reactivity with other Bcl-2 family members, including Bcl-2, Bcl-X, Bax or Mcl-l. Immunohistochemical studies show that Bak expression is widespread, and may show some correlation with the apoptopic state of cells. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 ml of Serum liquid |
| Uses: | This antibody is useful for Western Blot, Immunohistochemistry-Paraffin |
| Localization: | Mitochondrial,Membrane; single-pass membrane protein |
| Control: | Human tonsil |
| Background: | Bak or Bcl2 homologous antagonist is a member of the Bcl2 family of proteins. The Bcl-2 related proteins interact with one another through the formation of homo and heterodimers. The susceptibility of cells to apoptotic stimuli is thought to be controlled by the relative ratios of the different Bcl2 family proteins. Bak has been demonstrated to accelerate the rate of apoptosis in growth factor deprived murine lymphoid, neuronal and fibroblastic cell lines. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. Bak also interacts with the tumor suppressor P53 after exposure to cell stress. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Apoptosis Regulator Bak antibody, anti-BAK 1 antibody, anti-BAK antibody, anti-BAK like antibody, anti-Bak NT antibody, anti-BAK1 antibody, anti-Bcl 2 homologous antagonist/killer antibody, anti-Bcl 2 like 7 protein antibody, anti-Bcl2 homologous antagonist killer antibody, anti-Bcl2 like 7 Protein antibody, anti-BCL2-antagonist/killer 1 antibody, anti-BCL2L7 antibody, anti-CDN 1 antibody, anti-CDN1 antibody, anti-Cell death inhibitor 1 antibody, anti-MGC117255 antibody, anti-MGC3887 antibody, anti-NBak antibody, anti-Pro apoptotic protein BAK antibody |
| ProteinTarget: | Bak |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Krajewski, S. et al. (1996) Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family. Cancer Res. 56: 2849-2855. |
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