| CatalogCode: | NB100-66342 |
| ProductName: | SUMO-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-SUMO-1 |
| Clonality: | Polyclonal |
| Immunogen: | 14 amino acid peptide sequence near the amino terminus of human SUMO-1. |
| Specificity: | NB100-66342 detects an epitope within the N-terminal (NT) region of small ubiquitin-related modifier-1 (SUMO-1). SUMO-1 is an 11kD protein which structurally related to ubiquitin, and is added to proteins as a form of post-translational modification known as sumoylation. Sumoylation can be cell cycle regulated, stimulated upon stress or induced by DNA damage, and binding elicits individual effects for each protein. Effects include changes to protein stability, nuclear-cytosolic transport, and transcriptional regulation (mostly transcriptional repression).Alternate transcriptional splice variants encoding different isoforms have been characterized. |
| CrossReactivity: | Reacts with: Mouse, Rat |
| Packaging: | 0.1 mg Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Nuclear; nuclear envelope and nuclear speckles. Also cytoplasmic. |
| Background: | Sumo 1 is a ubiquitin-like protein which binds to a wide range of target proteins. It does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Sumo 1 plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis, autophagy and signal transduction. It is involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Sumo 1 is also known to form a complex with RanGAP1. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-GAP modifying protein 1 antibody, anti-GMP 1 antibody, anti-GMP1 antibody, anti-PIC 1 antibody, anti-PIC1 antibody, anti-SENP2 antibody, anti-Sentrin 1 antibody, anti-Sentrin antibody, anti-Small ubiquitin related modifier 1 antibody, anti-SMT3 antibody, anti-SMT3 homolog 3 antibody, anti-SMT3 suppressor of mif two 3 homolog 1 antibody, anti-SMT3C antibody, anti-SMT3H3 antibody, anti-Sumo1 antibody, anti-Ubiquitin homology domain protein PIC1 antibody, anti-Ubiquitin Like 1 antibody, anti-Ubiquitin like protein SMT3C antibody, anti-Ubiquitin like protein UBL1 antibody, anti-UBL 1 antibody, anti-UBL1 antibody |
| ProteinTarget: | SUMO-1 (N-TERMINAL) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Melchior, F. and Hengst, L. (2002) SUMO-1 and p53. Cell Cycle. 1: 245-249. 2. Verger, A et al. (2003) Modification with SUMO. A role in transcriptional regulation. EMBO Rep. 4: 137-142. |
| NotesMain: | Western Blotting: Detects a band of approximately 15kDa in HL-60 cell lysates. |
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