| CatalogCode: | NB100-66323 |
| ProductName: | SHP2 Antibody |
| Product Description: | Rabbit Polyclonal anti-SHP2 |
| Clonality: | Polyclonal |
| Immunogen: | 14 amino acid peptide sequence near the carboxy terminus of human SHP2. |
| Specificity: | NB100-66323 recognises src homology 2 domain containing tyrosine phosphatase (SHP2), a 68 kDa member of the protein tyrosine phosphatase family. SHP2 acts downstream of growth factor receptors and cytoplasmic protein tyrosine kinases which transduce signals from cell surface to the nucleus. The recruitment and activation of SHP2 is mediated through the binding of CD172a to its ligand CD47. SHP2 regulates a variety of cellular processes. These include transcription, embryonic development, cell growth, cell migration, differentiation, mitotic cycle, haematopoiesis and oncogenic transformation. As a result, dysregulation of the SHP2 gene has been linked to LEOPARD, Noonan and Noonan-like syndrome as well as acute myeloid leukaemia. SHP2 is ubiquitously expressed, with highest levels found in heart, brain, and skeletal muscle. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of affinity chromatography Purified IgG |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Cytoplasmic |
| Background: | The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-BPTP 3 antibody, anti-BPTP3 antibody, anti-CFC antibody, anti-MGC14433 antibody, anti-Noonan syndrome 1 antibody, anti-Noonan syndrome 1 protein tyrosine phosphatase 2C antibody, anti-NS 1 antibody, anti-NS1 antibody, anti-Protein tyrosine phosphatase 2C antibody, anti-Protein Tyrosine Phosphatase Non receptor Type 11 antibody, anti-PTP 1D antibody, anti-PTP 2C antibody, anti-PTP1D antibody, anti-PTP2C antibody, anti-PTPN 11 antibody, anti-PTPN11 antibody, anti-SAP2 antibody, anti-SH PTP2 antibody, anti-SH PTP3 antibody, anti-SH2 domain containing protein tyrosine phosphatase 2 antibody, anti-SHIP2 antibody, anti-SHP 2 antibody, anti-SHPTP 2 antibody, anti-SHPTP2 antibody, anti-SHPTP3 antibody, anti-SIT protein precursor antibody, anti-Syp antibody, anti-Tyrosine protein phosphatase non receptor type 11 antibody |
| ProteinTarget: | SHP2 (C-TERMINAL) |
| PackageSize: | 0.1 mg |
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