| CatalogCode: | | NB100-66274 |
| ProductName: | | PAK2 Antibody |
| Product Description: | | Rabbit Polyclonal anti-PAK2 |
| Clonality: | | Polyclonal |
| Immunogen: | | 14 amino acid peptide sequence near the carboxy terminus of human PAK2. |
| Specificity: | | NB100-66274 recognises p21-activated kinase-2 (PAK2), a ubiquitously expressed, 64kDa, serine/threonine protease found at higher levels in skeletal muscle, ovary, thymus and spleen. p21-activated kinases (PAKs) bind activated Cdc42 and Rac via a Cdc42/Rac interactive binding (CRIB) domain. Group 1 PAK kinases (PAK1, 2 and 3) regulate the activity of an adjacent conserved autoinhibitory domain and are associated with cellular processes, including cytoskeleton rearrangement, apoptosis and MAP kinase signalling. Group 2 PAKs (PAK4, 5, and 6) lack the autoinhibitory domain and are not activated by Cdc42/Rac binding.PAK2 has a cytostatic effect on cells and is activated in response to cellular stresses such hyperosmolarity, serum starvation, contact inhibition and DNA damage from radiation and chemicals. Unlike other PAKs, PAK2 can be activated by proteolytic cleavage to generate a constitutively active fragment, PAK2p34, which induces a cell death response. This induction is thought to be regulated by Rho GTPase-activating protein 10 which inhibits the protein kinase activity of PAK2p34 and causes it to localise to the perinuclear region instead of the nucleus. PAK2 may also play a role in X-linked mental retardation. |
| CrossReactivity: | | Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg of affinity chromatography Purified IgG |
| Uses: | | This antibody is useful for Western Blot |
| Background: | | The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | Phosphate buffered saline |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-CB422 antibody, anti-Gamma PAK antibody, anti-hPAK65 antibody, anti-p21CDKN1A activated kinase 2 antibody, anti-p65PAK antibody, anti-PAK65 antibody, anti-PAKgamma antibody, anti-S6 H4 kinase antibody, anti-Serine threonine protein kinase PAK 2 antibody |
| ProteinTarget: | | PAK2 (C-TERMINAL) |
| PackageSize: | | 0.1 mg |
| more information: | | company product webpage |
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