| CatalogCode: | | NB100-66263 |
| ProductName: | | NOD2 Antibody |
| Product Description: | | Rabbit Polyclonal anti-NOD2 |
| Clonality: | | Polyclonal |
| Immunogen: | | 14 amino acids at carboxy terminus of human NOD2. |
| Specificity: | | NB100-66263 recognises NOD2, an intracellular protein of 100kDa, which belongs to the NOD (nucleotide binding oligomerisation domain) family. The NOD family comprises at present more than 20 different mammalian NOD-LRR (leucine-rich repeat) proteins, which are involved in the regulation of apoptosis and the immune response.NOD2 has been shown to be constitutively or inducibly expressed in monocytes, macrophages, T and B cells, dendritic cells, as well as intestinal epithelial cells. A specific motif of peptidoglycan (PGN), muramyl dipeptide (MDP), has been identified as the sole ligand of NOD2.NOD2 and Toll-like receptors (TLR) are emerging as key mediators of innate host defence in the intestinal mucosa, crucially involved in maintaining mucosal and commensal homeostasis.Mutations in the gene encoding NOD2 are a major susceptibility factor underlying a significant subgroup of patients with Crohn's disease. |
| CrossReactivity: | | Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg of affinity chromatography Purified IgG |
| Uses: | | This antibody is useful for Western Blot |
| Localization: | | Cytoplasmic |
| Background: | | CARD15 (Nod2) is a member of the Nod1/Apaf-1 family of intracellular proteins that contain an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and a C-terminal regulatory domain. CARD15 induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It also confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Unlike Nod1, this homologue is primary expressed in monocytes. Defects in CARD15 are associated with Blau Syndrome (BS) and Crohn's Disease (CD), and are a cause of susceptibility to ulcerative colitis. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | Phosphate buffered saline |
| ListPrice: | | 285 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-CARD15 antibody, anti-ACUG antibody, anti-Arthrocutaneouveal granulomatosis antibody, anti-BLAU antibody, anti-CARD15 antibody, anti-Caspase recruitment domain protein 15 antibody, anti-CD antibody, anti-IBD1 antibody, anti-Inflammatory bowel disease protein 1 antibody, anti-LRR containing protein antibody, anti-Nod2 antibody, anti-NOD2 protein antibody, anti-NOD2B antibody, anti-nucleotide binding oligomerization domain 2 antibody, anti-PSORAS1 antibody |
| ProteinTarget: | | NOD2 (C-TERMINAL) |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | 1. Inohara, N. and Nunez, G. (2003) NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3:371-382 2. Cario, E. (2005) Bacterial interactions with cells of the intestinal mucosa: toll-like receptors and NOD2. Gut. 54:1182-1193. 3. Girardin, S. et al. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278:8869-8872. |
| NotesMain: | | Western Blotting: Detects a band of approximately 100kDa in HeLa cell lysate. |
| more information: | | company product webpage |
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