| CatalogCode: | NB100-66210 |
| ProductName: | IKK BETA Antibody |
| Product Description: | Rabbit Polyclonal anti-IKK BETA |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acids 662-680 of human IKK Beta |
| Specificity: | IKK is a serine protein kinase. The IKK complex consists of an alpha IKK subunit and a beta IKK subunit. Both IKK alpha and IKK beta subunits are required for NFkB activation.NB100-66210 recognise IKK beta and does not cross react with IKK alpha or IKK gamma |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of affinity chromatography Purified IgG |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Cytoplasmic |
| Background: | IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK-1. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-I kappa B kinase 2 antibody, anti-I kappa B kinase beta antibody, anti-IkBKB antibody, anti-IKK 2 antibody, anti-IKK B antibody, anti-IKK2 antibody, anti-IKKB antibody, anti-Inhibitor of kappa light chain gene enhancer in B cells antibody, anti-Inhibitor of kappa light polypeptide gene enhancer in B cells antibody, anti-Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody, anti-Inhibitor of nuclear factor kappa B kinase beta subunit antibody, anti-Inhibitor of nuclear factor kappa B kinase subunit beta antibody, anti-MGC131801 antibody, anti-NFKBIKB antibody, anti-Nuclear factor NF kappa B inhibitor kinase beta antibody, anti-Nuclear factor of kappa light chain gene enhancer in B cells inhibitor antibody |
| ProteinTarget: | IKK BETA (aa662-680) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Woronicz, J.D. et al. (1997) I Kappa B kinase-beta: NF-kappa B activation and complex formation with I Kappa B kinase-alpha and NIK. Science 278: 866-9. |