| CatalogCode: | | NB100-66087 |
| ProductName: | | CD253 Antibody |
| Product Description: | | Rabbit Polyclonal anti-CD253 |
| Clonality: | | Polyclonal |
| Immunogen: | | Peptide from C-terminus of human CD253 (TRAIL) |
| Specificity: | | NB100-66087 recognises the 32kD apoptosis related protein designated TRAIL (TNF-related apoptosis-inducing ligand) TRAIL also known as CD253, is a type II membrane protein expressed in a variety of tissues. Receptors for TRAIL have recently been identified and termed DR4 and DR5. |
| CrossReactivity: | | Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg of ion exchange chromatography Purified IgG |
| Uses: | | This antibody is useful for Western Blot |
| Localization: | | Type II membrane protein |
| Background: | | Apoptosis or programmed cell death is induced in cells by a group of death domain containing receptors. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases. The signals ultimately cause degradation of chromosomal DNA by activating DNase. TRAIL (TNF related apoptosis induced ligand) or Apo 2L initiates apoptosis of tumor cells by binding to either of its receptors, DR4 or DR5. These receptors consist of an extracellular TRAIL binding domain and a cytoplasmic "death domain". In addition, two decoy receptors for TRAIL have also been identified. These receptors, designated DcR1 and DcR2, lack the death domain. Binding of TRAIL to either of these receptors, therefore, does not transmit the death signal. Thus, these receptors represent a novel way of regulating cell sensitivity to a pro-apoptotic cytokine at the cell surface. TRAIL is expressed predominantly in spleen, lung, and prostate but also in many other tissues. TRAIL is a type II membrane protein from the TNF family. The human form of the protein is 281 amino acids in length, whereas the murine form is 291 amino acids. The two forms share 65% identity. Recombinant human TRAIL monomer has a molecular mass of approximately 21 kDa. Due to glycosylation, recombinant human TRAIL migrates as a 24 kDa protein in SDS PAGE. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | Phosphate buffered saline |
| ListPrice: | | 285 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-TRAIL antibody, anti-Apo 2 ligand antibody, anti-Apo 2L antibody, anti-APO2L antibody, anti-CD 253 antibody, anti-CD253 antibody, anti-CD253 antigen antibody, anti-Protein TRAIL antibody, anti-TL 2 antibody, anti-TL2 antibody, anti-TNF Related Apoptosis Inducing Ligand antibody, anti-TNF related apoptosis inducing ligand TRAIL antibody, anti-TNFSF 10 antibody, anti-TNFSF10 antibody, anti-TNFSF10 protein antibody, anti-TRAIL antibody, anti-TRAIL PEN antibody, anti-Tumor Necrosis Factor (ligand) Superfamily Member 10 antibody |
| ProteinTarget: | | CD253 (C-TERMINAL) |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | 1. Wiley, S.R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3: 673-682. 2. Pitti, R.M. et al. (1996) Induction of apoptosis of Apo-2 ligand, a new member of the tumor recrosis factor cytokine family. J. Biol. Chem. 271: 12687-12690. |
| more information: | | company product webpage |
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