| CatalogCode: | NB100-66080 |
| ProductName: | CD172a Antibody |
| Product Description: | Rabbit Polyclonal anti-CD172a |
| Clonality: | Polyclonal |
| Immunogen: | Peptide from C terminus of human SIRP alpha 1 |
| Specificity: | NB100-66080 recognises human CD172a, also known as signal regulatory protein (SIRP) alpha, SHPS-1, my D-1, BIT and p84. CD172a is a recently cloned glycoprotein which is a substrate of many activated tyrosine kinases. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of ion exchange chromatography Purified IgG |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | Protein tyrosine phosphatases (PTPases) SHP1 and SHP2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1),SHPS1 , MyD1, BIT and p84. SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP2. SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-BIT antibody, anti-Brain Ig like molecule with tyrosine based activation motifs antibody, anti-Brain immunoglobulin like molecule with tyrosine based activation motifs antibody, anti-CD 172a antibody, anti-CD172a antibody, anti-CD172a antigen antibody, anti-Inhibitory receptor SHPS 1 antibody, anti-Inhibitory receptor SHPS1 antibody, anti-Macrophage fusion receptor antibody, anti-MFR antibody, anti-MYD 1 antibody, anti-Myd 1 antigen antibody, anti-MYD1 antibody, anti-Myd1 antigen antibody, anti-p84 antibody, anti-Protein tyrosine phosphatase non receptor type substrate 1 antibody, anti-PTPNS 1 antibody, anti-PTPNS1 antibody, anti-SHP substrate 1 antibody, anti-SHPS 1 antibody, anti-SHPS1 antibody, anti-Signal regulatory protein alpha 1 antibody, anti-Signal regulatory protein alpha antibody, anti-Signal regulatory protein alpha type 1 antibody, anti-Signal regulatory protein alpha type 2 antibody, anti-SIRP A antibody, anti-SIRP alpha 1 antibody, anti-SIRP alpha 2 antibody, anti-Sirp alpha 3 antibody, anti-SIRP antibody, anti-SIRPA antibody, anti-SIRPalpha antibody, anti-SIRPalpha1 antibody, anti-SIRPalpha2 antibody, anti-Sirpalpha3 antibody, anti-Tyrosine phosphatase SHP substrate 1 antibody, anti-Tyrosine protein phosphatase non receptor type substrate 1 antibody, anti-Tyrosine protein phosphatase non receptor type substrate antibody |
| ProteinTarget: | CD172a |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386: 181-186. |
order or
more information: | company product webpage |
| request information: |
|
|