| CatalogCode: | NB100-66075 |
| ProductName: | CASPASE-9 Antibody |
| Product Description: | Rabbit Polyclonal anti-CASPASE-9 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acids 299-318 of human caspase-9 |
| Specificity: | Caspase-9 (also known as ICE-LAP6, McL6 and Apaf-3) plays a central role in programmed cell death.Following activation (induced by the binding of Apaf-1), caspase-9 cleaves and activates caspase-3.NB100-66075 recognises the 46kD caspase-9 in Western blots |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of affinity chromatography Purified IgG |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Cytoplasmic and Mitochondrial |
| Background: | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-APAF 3 antibody, anti-APAF3 antibody, anti-Apoptosis related cysteine peptidase antibody, anti-Apoptotic protease activating factor 3 antibody, anti-Apoptotic protease Mch 6 antibody, anti-CASP 9 antibody, anti-CASP9 antibody, anti-Caspase 9 precursor antibody, anti-Caspase 9c antibody, anti-Caspase9 antibody, anti-EC 3.4.22. antibody, anti-ICE LAP6 antibody, anti-ICE like apoptotic protease 6 antibody, anti-MCH6 antibody, anti-RNCASP9 antibody |
| ProteinTarget: | CASPASE-9 (aa299-318) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Li, P. et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptosis protease cascade. Cell 91: 479-489. 2. Pan, G. et al. (1998) Caspase-9, Bcl-XL and Apaf-1 form a ternary complex. J. Biol. Chem. 273: 5841-5845. |
order or
more information: | company product webpage |
| request information: |
|