| CatalogCode: | | NB100-66062 |
| ProductName: | | BLNK Antibody |
| Product Description: | | Goat Polyclonal anti-BLNK |
| Clonality: | | Polyclonal |
| Immunogen: | | Peptide with the sequence C-KDSTRLKYAVKVS from the C terminus of the protein Sequence according to the Entrez Gene accession number NP_37446 |
| Epitope: | | C-KDSTRLKYAVKVS |
| CrossReactivity: | | Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg of Purified IgG |
| Uses: | | This antibody is useful for Western Blot |
| Localization: | | Cell Membrane and Cytoplasmic. BCR activation results in the translocation to membrane fraction. |
| Background: | | BLNK (B cell linker protein) is an adaptor molecule that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). This activation leads to an increase in the tyrosine phosphorylation of a number of proteins due to activation of nonreceptor protein tyrosine kinases (PTK) including Syk, which is responsible for the tyrosine phosphorylation of BLNK. BLNK is cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kDa in SDS/PAGE (alternatively spliced forms of human BLNK). Mapping of the tyrosine residues in BLNK reveal three tyrosines that bind PLC-gamma2, and two tyrosines that bind the Tec family kinase Btk, the Vav nucleotide exchange factor and the adaptor Nck. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris buffered saline |
| ListPrice: | | 295 |
| AppSummary: | | WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-B cell adapter containing SH2 domain protein antibody, anti-B cell adapter containing Src homology 2 domain protein antibody, anti-B cell linker antibody, anti-B cell linker protein antibody, anti-BASH antibody, anti-Bca antibody, anti-BLNK s antibody, anti-Cytoplasmic adapter protein antibody, anti-Ly 57 antibody, anti-Ly57 antibody, anti-Lymphocyte antigen 57 antibody, anti-Lyw 57 antibody, anti-Lyw57 antibody, anti-MGC111051 antibody, anti-SLP 65 antibody, anti-SLP65 antibody, anti-Src homology 2 domain containing leukocyte protein of 65 kDa antibody |
| ProteinTarget: | | BLNK |
| PackageSize: | | 0.1 mg |
| more information: | | company product webpage |
|