| CatalogCode: | NB100-66029 |
| ProductName: | AKT1 Antibody |
| Product Description: | Rabbit Polyclonal anti-AKT1 (POLYCLONAL) |
| Clone: | POLYCLONAL |
| Clonality: | Polyclonal |
| Immunogen: | A 16 amino acid peptide located near the human Akt1 amino-terminus. |
| Specificity: | NB100-66029 recognises the N-terminal region of Akt1, a 48kDa protein kinase forming part of the PI3K-Akt signalling pathway, known to regulate cell growth, proliferation and survival. The PI3K-Akt1 pathway is negatively regulated by the tumour suppressor PTEN.Excessive Akt1 activation can lead to the formation of malignant tumours, and has been associated with prostate cancer progression. |
| CrossReactivity: | Reacts with: Mouse, Rat |
| Packaging: | 0.1 mg of affinity chromatography Purified IgG |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Cytoplasmic, and nuclear after activation by integrin linked protein kinase 1 (ILK1). |
| Background: | The serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific. In the developing nervous system AKT is a critical mediator of growth factor induced neuronal survival. Survival factors can suppress apoptosis in a transcription independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene (referenced from entrez gene). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-C AKT antibody, anti-CAKT antibody, anti-MGC9965 antibody, anti-Murine thymoma viral (vakt) oncogene homolog 1 antibody, anti-Oncogene AKT1 antibody, anti-PKB Akt antibody, anti-PKB alpha antibody, anti-PKB antibody, anti-PKBalpha antibody, anti-PRKBA antibody, anti-Protein Kinase B Alpha antibody, anti-RAC Alpha antibody, anti-RAC alpha serine/threonine protein kinase antibody, anti-RAC antibody, anti-RAC PK Alpha antibody, anti-RAC Serine/Threonine Protein Kinase antibody, anti-V AKT Murine Thymoma Viral Oncogene Homolog 1 antibody, anti-vAKT Murine Thymoma Viral Oncogene Homolog 1 antibody, anti-VAKT Murine Thymona Viral Oncogene 1 antibody |
| ProteinTarget: | AKT1 (N-TERMINAL) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Stern, D. F. (2004) More than a marker?Phosphorylated Akt in prostate carcinoma. Clin. Cancer Res. 10: 6407-6410. |
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