| CatalogCode: | NB100-66023 |
| ProductName: | ACINUS Antibody |
| Product Description: | Rabbit Polyclonal anti-ACINUS |
| Clonality: | Polyclonal |
| Immunogen: | Peptide TRTALHGVKWPQSNPK which corresponds to a region near the C-terminus of the cleaved peptide. |
| Epitope: | TRTALHGVKWPQSNPK |
| Specificity: | NB100-66023 recognises Acinus (apoptosis chromatin condensation inducer in the nucleus), an inducer of chromatin condensation. The antibody recognises three different splice forms of Acinus, designated Acinus L, Acinus S and Acinus S'.NB100-66023 recognises a region near the C-terminus of the cleaved active peptide p17. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of Purified IgG |
| Uses: | This antibody is useful for Western Blot |
| Localization: | Nuclear |
| Background: | Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids), Acinus S (583 amino acids) and Acinus S' (614 amino acids). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ACIN 1 antibody, anti-ACIN1 antibody, anti-ACINUS antibody, anti-ACN antibody, anti-Apoptotic chromatin condensation inducer 1 antibody, anti-Apoptotic chromatin condensation inducer in the nucleus antibody, anti-DKFZp667N107 antibody, anti-KIAA0670 antibody |
| ProteinTarget: | ACINUS |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Sahara, S. et al. (1999) Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Nature. 401: 168-73 |