| CatalogCode: | NB100-65932 |
| ProductName: | CD95 Antibody |
| Product Description: | Mouse Monoclonal anti-CD95 (LOB 3/11) |
| Clone: | LOB 3/11 |
| Clonality: | Monoclonal |
| Immunogen: | Fusion protein comprising extracellular domain of human Fas linked to human Fc |
| Specificity: | NB100-65932 recognises the human CD95 cell surface antigen, also known as Fas. CD95 is a 40-50kD glycoprotein expressed by activated T and B cells, NK cells and thymocytes.LOB 3/11 induces apoptosis of cell lines expressing high levels of CD95. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for immunoprecipitation, flow cytometry / FACS analysis |
| Localization: | Single pass type I membrane protein (isoform 1); Secreted (isoforms 2 to 6). |
| Background: | CD95, also known as FAS or APO1, is a 36 kDa cell surface type I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS PAGE. CD95 is a member of the TNF receptor family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl terminal region of the molecule. The binding of adaptor molecules to this DD is responsible for transmitting the death signal for apoptosis. Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase 8 that together with the receptor form the death inducing signaling complex (DISC). CD95/CD95L is involved in the peripheral deletion of activated mature T cells at the end of the immune response and defects in this pathway predispose to autoimmune disorders. CD95 is also involved in killing of targets such as virus infected cells or cancer cells and killing of inflammatory cells at immune privileged sites. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 295 |
| AppSummary: | IP, FACS |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ALPS1A antibody, anti-APO 1 antibody, anti-Apo 1 antigen antibody, anti-APO1 cell surface antigen antibody, anti-Apoptosis antigen 1 antibody, anti-Apoptosis APO1 antigen 1 antibody, anti-Apoptosis mediating surface antigen FAS antibody, anti-APT1 antibody, anti-CD 95 antibody, anti-CD95 antibody, anti-CD95 antigen antibody, anti-Fas (TNF receptor superfamily member 6) antibody, anti-FAS antibody, anti-FAS Antigen antibody, anti-FAS1 antibody, anti-FASL receptor antibody, anti-FASLG receptor antibody, anti-FASTM antibody, anti-TNF receptor superfamily member 6 antibody, anti-TNFR6 antibody, anti-TNFRSF6 antibody, anti-Tumor necrosis factor receptor superfamily member 6 antibody |
| ProteinTarget: | CD95 |
| PackageSize: | 0.2 mg |
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