| CatalogCode: | NB100-65889 |
| ProductName: | CD244 Antibody |
| Product Description: | Mouse Monoclonal anti-CD244 (2B4.69) |
| Clone: | 2B4.69 |
| Clonality: | Monoclonal |
| Immunogen: | CD244 Fusion protein. |
| Specificity: | NB100-65889 is specific for the CD244 cell surface antigen, also known as natural killer receptor 2B4 (NKG2B4).The glycoprotein CD244 is a member of the SLAM family of receptors which is expressed on natural killer (NK) cells, gamma delta T cells, CD14+ monocytes, and a subset of CD8+ T cells.CD244 was originally identified as an activating receptor on NK cells, although recent studies suggest that the receptor may have a wide range of activities including NK cell activation, costimulation, or even inhibition, depending on the cell type and stage of differentiation. The ligand of 2B4 is CD48, a GPI-anchored membrane protein also belonging to the SLAM family. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for immunoprecipitation, flow cytometry / FACS analysis |
| Localization: | Cell Membrane; single-pass type I membrane protein (potential). |
| Background: | CD244 is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. CD244 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness. Although there have been several molecules shown to interact with CD244, the signaling mechanism ofCD244-mediated activation of NK cells is still unknown. It is a high affinity receptor for CD48. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline pH7.4 |
| ListPrice: | 295 |
| AppSummary: | IP, FACS |
| SpeciesSummary: | Hu |
| ALTnames: | anti-2B4 antibody, anti-CD244 molecule natural killer cell receptor 2B4 antibody, anti-h2B4 antibody, anti-NAIL antibody, anti-Natural killer cell receptor 2B4 antibody, anti-NK cell activation inducing ligand antibody, anti-NK cell type I receptor protein 2B4 antibody, anti-NKR2B4 antibody, anti-Nmrk antibody, anti-p38 antibody, anti-SLAMF4 antibody |
| ProteinTarget: | CD244 |
| PackageSize: | 0.2 mg |
order or
more information: | company product webpage |
| request information: |
|
|