| CatalogCode: | NB100-65822 |
| ProductName: | MMP-2 Antibody |
| Product Description: | Sheep Polyclonal anti-MMP-2 |
| Clonality: | Polyclonal |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml of Purified IgG |
| Uses: | This antibody is useful for Immunohistochemistry-Paraffin, Western Blot |
| Background: | The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG |
| Host_Name: | Sheep |
| ListPrice: | 365 |
| AppSummary: | IHC-P, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | MMP-2 |
| PackageSize: | 1 ml |
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