| CatalogCode: | NB100-65634 |
| ProductName: | C-JUN Antibody |
| Product Description: | Rabbit Polyclonal anti-C-JUN |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic C-terminal peptide (aa320-340) of the human c-jun gene product, coupled to Keyhole Limpet Haemocyanin. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 ml of Ammonium Sulphate fractionation Purified IgG |
| Uses: | This antibody is useful for Immunohistochemistry-Paraffin |
| Localization: | Nuclear |
| Background: | The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, pH 7.2 |
| ListPrice: | 285 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Activator Protein 1 antibody, anti-AP 1 antibody, anti-AP1 antibody, anti-Enhancer Binding Protein AP1 antibody, anti-Jun Activation Domain Binding Protein antibody, anti-JUN antibody, anti-Jun oncogene antibody, anti-JUN protein antibody, anti-JUNC antibody, anti-p39 antibody, anti-Proto oncogene cJun antibody, anti-Transcription Factor AP1 antibody, anti-V jun avian sarcoma virus 17 oncogene homolog antibody, anti-vJun Avian Sarcoma Virus 17 Oncogene Homolog antibody |
| ProteinTarget: | C-JUN |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. (0) Bohmann et al, Science 238, 1386 (1987). |
| NotesMain: | Immunohistology: Formalin or Zamboni's fixed tissue by vibratome or after paraffin wax embedding are suitable. Mild trypsinisation may be used to intensify staining of paraffin wax embedded material. |
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