| CatalogCode: | NB100-65392 |
| ProductName: | CD62P Antibody |
| Product Description: | Mouse Monoclonal anti-CD62P (Psel.KO.2.7) |
| Clone: | Psel.KO.2.7 |
| Clonality: | Monoclonal |
| Immunogen: | P-selectin transfected 300.19 cells. |
| Specificity: | NB100-65392 recognises the CD62P cell surface antigen, a 140kD glycoprotein also known as P-selectin.CD62P is expressed by activated platelets and endothelial cells, and plays an important role in adhesive processes between leucocytes and endothelial cells. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, immunoprecipitation, flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | CD62P is a member of the small selectin family of cellular adhesion molecules, which also includes CD62E and CD62L. Its structure, similar to the other members of the selectin family, consists of an N terminal lectin like domain of C type, followed by an epidermal growth factor like motif, a series of short consensus repeats, a transmembrane domain, and a cytoplasmic tail. The CD62P antigen is a 140 kDa glycoprotein, located in the alpha granules and the dense granules of platelets and endothelial cells. Activation of these cells results in rapid mobilization of CD62P from the storage granules to the cell surface. Activated platelets have a stable CD62P expression, while the endothelial cells lose CD62P expression within 1 h of activation, because of endocytosis of the molecule. CD62P is also expressed on megakaryocytes, but resting platelets and endothelial cells show no surface staining of CD62P. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline pH7.4 |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr, IP, FACS |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CD62P antibody, anti-Antigen CD62 antibody, anti-CD62 antibody, anti-CD62P antigen antibody, anti-FLJ45155 antibody, anti-GMP 140 antibody, anti-GMP140 antibody, anti-GMRP antibody, anti-Granule membrane protein 140 antibody, anti-Granule membrane protein 140kDa antibody, anti-Granulocyte membrane protein antibody, anti-GRMP antibody, anti-LECAM 3 antibody, anti-LECAM3 antibody, anti-Leukocyte endothelial cell adhesion molecule 3 antibody, anti-P Selectin antibody, anti-PADGEM antibody, anti-Platelet activation dependent granule external membrane protein antibody, anti-PSEL antibody, anti-Selectin P (granule membrane protein 140kDa antigen CD62) antibody, anti-SELP antibody |
| ProteinTarget: | CD62P |
| PackageSize: | 0.2 mg |
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