| CatalogCode: | NB100-65341 |
| ProductName: | CD322 Antibody |
| Product Description: | Rat Monoclonal anti-CD322 (CRAM-19 H36) |
| Clone: | CRAM-19 H36 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant soluble JAM-2 |
| Specificity: | NB100-65341 recognises murine junctional adhesion molecule-2 (JAM-2), a 45kD transmembrane protein a member of the immunoglobulin superfamily otherwise known as CD322. In adult murine tissue CD322 expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney.In humans, CD322 expression is not restricted to endothelial cells, but is also expressed on human lymphocytes. |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, immunoprecipitation, flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | Junctional adhesion molecule 2 (JAM2), also know as JAMC, is a cell adhesion molecule (CAM). JAM2 is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM2 belongs together with JAMA (JAM or JAM1) and JAMB (VEJAM or JAM3) to a family of adhesion proteins with a VC2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell to cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM2 is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM2 expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. In humans, JAM2 expression is not restricted to endothelial cells, but is also expressed on human lymphocytes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline pH7.4 |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr, IP, FACS |
| SpeciesSummary: | Mu |
| ALTnames: | anti-Junctional Adhesion Molecule 2 antibody, anti-C21orf43 antibody, anti-CAM antibody, anti-CD 322 antibody, anti-CD322 antibody, anti-CD322 antigen antibody, anti-JAM 2 antibody, anti-JAM B antibody, anti-JAM IT/VE JAM antibody, anti-JAM2 antibody, anti-JAMB antibody, anti-JAMC antibody, anti-Junction adhesion molecule B antibody, anti-Junction adhesion molecule C antibody, anti-PRO 245 antibody, anti-PRO245 antibody, anti-Vascular endothelial junction associated molecule antibody, anti-VE JAM antibody, anti-VEJAM antibody |
| ProteinTarget: | CD322 |
| PackageSize: | 0.25 mg |
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