| CatalogCode: | NB100-65280 |
| ProductName: | CD11a Antibody |
| Product Description: | Mouse Monoclonal anti-CD11a (WT.1) |
| Clone: | WT.1 |
| Clonality: | Monoclonal |
| Immunogen: | Splenic PHA Blasts |
| Specificity: | NB100-65280 reacts with the rat LFA-1 a chain (160-170kD) which is associated with the b chain (CD18; 95-100 kD). LFA-1 is one of the leucocyte integrins (b2 integrin) which plays an important role in leucocyte physiology. Functionally, this monoclonal inhibits homotypic aggregation of PHA blasts. It also blocks binding of rat lymphocytes to purified rat ICAM-1. |
| CrossReactivity: | Rat. Not yet tested in other species. |
| Packaging: | 0.2 mg protein G purified Mouse IgG. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, immunoprecipitation, flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | CD11a is a member of the integrin family of cell adhesion molecules. It is a glycoprotein expressed in combination with the CD18 beta chain. The complex is a member of the beta 2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM2, ICAM3. CD11a is expressed on thymocytes, T and B lymphocytes, granulocytes, monocytes, and macrophages. This antibody blocks CD11a functions. CD11a is expressed on human leucocytes, with greater expression on memory T cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | FACS, IP, IHC-Fr |
| SpeciesSummary: | Rt |
| ALTnames: | anti-Antigen CD11A antibody, anti-CD 11a antibody, anti-CD11a antigen antibody, anti-Integrin Alpha L antibody, anti-Integrin gene promoter antibody, anti-ITGAL antibody, anti-ITGAL protein antibody, anti-Leukocyte adhesion glycoprotein LFA 1 alpha chain antibody, anti-Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain antibody, anti-Leukocyte function associated molecule 1 alpha chain antibody, anti-LFA 1 alpha antibody, anti-LFA 1 antibody, anti-LFA 1A antibody, anti-LFA1A antibody, anti-Ly15 antibody, anti-Ly21 antibody, anti-Lymphocyte function associated antigen 1 antibody, anti-Lymphocyte Function Associated Antigen Type 1 alpha antibody, anti-p180 antibody |
| ProteinTarget: | CD11a |
| PackageSize: | 0.2 mg |
| GeneralRef: | 1. Tamatani, T., Kotani, M. and Miyasaka, M. (1991) Characterization of the rat leukocyte integrin, CD11/18, by the use of LFA-1 subunit-specific monoclonal antibodies. Eur. J. Immunol. 21: 627-633. 2. Tamatani, T., Kotani, M., Tanaka, M and Miyasaka, M. (1991) Molecular mechanisms underlying lymphocyte recirculation II: Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells. Eur. J. Immunol. 21: 855-858. |
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