| CatalogCode: | NB100-65253 |
| ProductName: | PARKIN PEPTIDE Antibody |
| Product Description: | Goat Polyclonal anti-PARKIN PEPTIDE |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide |
| Specificity: | The parkin gene was discovered on chromosome 6 and is responsible for an early onset form of autosomal recessive juvenile Parkinson disease. It is expressed in various regions of the brain incuding the substantia nigra, as well as the heart, testes and skeletal muscle. It shows some similarities to ubiquitin at the N-terminus. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml of Purified IgG |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot, ELISA |
| Localization: | Cytoplasmic |
| Background: | Parkinson's Disease, the second most common neurodegenerative disease after Alzheimer's Disease, is characterized by the loss of dopaminergic neurons and the presence of Lewy bodies (comprised of alpha synuclein and parkin inclusions). Autosomal Recessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson's Disease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, has a suggested role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin while functionally it acts as a RING type ubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | PBS buffer, pH 7.2 |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| ALTnames: | anti-AR JP antibody, anti-E3 ubiquitin protein ligase parkin antibody, anti-FRA6E antibody, anti-LPRS 2 antibody, anti-LPRS2 antibody, anti-PARK 2 antibody, anti-PARK2 antibody, anti-Parkinson disease (autosomal recessive juvenile) 2 antibody, anti-Parkinson disease protein 2 antibody, anti-Parkinson juvenile disease protein 2 antibody, anti-PDJ antibody, anti-PRKN 2 antibody, anti-PRKN antibody, anti-PRKN2 antibody, anti-Ubiquitin E3 ligase PRKN antibody |
| ProteinTarget: | PARKIN PEPTIDE |
| PackageSize: | 1 ml |
| GeneralRef: | 1. (0) Kitada, T., et al. Mutations in the Parkin Gene Cause Autosomal Recessive Juvenile Parkinsonism. Nature 392: 605-608 (1998). |
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