| CatalogCode: | NB100-65204 |
| ProductName: | OREXIN A Antibody |
| Product Description: | Sheep Polyclonal anti-OREXIN A |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acids 2-14 of human orexin A peptide, conjugated to KLH. |
| Epitope: | Peptide sequence: PLPDCCRQKTCSC |
| Specificity: | NB100-65204 is specific for human orexin A. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml of Ammonium Sulphate fractionation Purified IgG |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, ELISA |
| Localization: | Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. |
| Background: | Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B(hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro orexin. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behaviour. Orexin A and orexin B bind to and activate two closely related G protein coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Dysfunction of the orexin peptide system has been linked to narcolepsy. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG |
| Host_Name: | Sheep |
| Buffer: | Phosphate buffered saline, pH 7.2 |
| ListPrice: | 295 |
| AppSummary: | ELISA, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| ALTnames: | anti-CRT 1 antibody, anti-HCRT antibody, anti-HCRT1 antibody, anti-Hypocretin (orexin) neuropeptide precursor antibody, anti-Hypocretin 1 antibody, anti-Hypocretin A antibody, anti-Hypocretin antibody, anti-Hypocretin neuropeptide precursor antibody, anti-Hypocretin1 antibody, anti-Orexin antibody, anti-OrexinA antibody, anti-OX antibody, anti-PPORX antibody, anti-PPOX antibody |
| ProteinTarget: | OREXIN A |
| PackageSize: | 1 ml |
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