| CatalogCode: | NB100-65199 |
| ProductName: | CORTICOTROPHIN RELEASING FACTOR Antibody |
| Product Description: | Mouse Monoclonal anti-CORTICOTROPHIN RELEASING FACTOR (5D5) |
| Clone: | 5D5 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic |
| Specificity: | Recognises a different epitope than clone 4H9 (2329-9907). 5D5 mAb binding decreases only partly after CA treatment. It is possible that the antigen determinant is exposed more openly after DEP modification of histidine residues, whereas this determinant becomes barely accesible after lysine modification. Human serum, containing CRF-binding protein, inhibits the binding of CRF to this antibody. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, ELISA |
| Localization: | Secreted |
| Background: | CRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | 0.09% Sodium Azide (NaN3) |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr, IHC-P, ELISA |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Corticoliberin precursor antibody, anti-Corticotropin releasing factor antibody, anti-Corticotropin releasing hormone antibody, anti-Corticotropin releasing hormone deficiency included antibody, anti-crf antibody, anti-crh antibody, anti-crh deficiency included antibody |
| ProteinTarget: | CORTICOTROPHIN RELEASING FACTOR |
| PackageSize: | 0.2 mg |