| CatalogCode: | NB100-65184 |
| ProductName: | THYROGLOBULIN Antibody |
| Product Description: | Rabbit Polyclonal anti-THYROGLOBULIN |
| Clonality: | Polyclonal |
| Immunogen: | Purified human thyroglobulin |
| Specificity: | NB100-65184 recognises the 670kD glycoprotein known as thyroglobulin, which is synthesized within the follicular epithelial cells of the thyroid gland.This antibody labels follicular cells in normal thyroid and colloid stored within thyroid follicles. It also labels neoplastic cells in cases of thyroid carcinoma. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml purified Rabbit IgG. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin |
| Localization: | Secreted |
| Control: | Thyroid |
| Background: | Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients. |
| Storage: | Store at +4oC or at -20oC if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recom |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 295 |
| AppSummary: | IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| ALTnames: | anti-AITD 3 antibody, anti-AITD3 antibody, anti-hTG antibody, anti-Tgn antibody |
| ProteinTarget: | THYROGLOBULIN |
| PackageSize: | 1 ml |
| NotesMain: | Immunohistology: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. |
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