| CatalogCode: | NB100-64903 |
| ProductName: | CD49d Antibody |
| Product Description: | Mouse Monoclonal anti-CD49d (44H6) |
| Clone: | 44H6 |
| Clonality: | Monoclonal |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of Purified IgG |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, flow cytometry / FACS analysis |
| Background: | Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity Purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| ListPrice: | 285 |
| AppSummary: | IHC-Fr, FACS |
| SpeciesSummary: | Hu |
| ProteinTarget: | CD49d |
| PackageSize: | 0.1 mg |
order or
more information: | company product webpage |
| request information: |
|
|