| CatalogCode: | NB100-64837 |
| ProductName: | CD106 Antibody |
| Product Description: | Rat Monoclonal anti-CD106 (MVCAM A (429)) |
| Clone: | MVCAM A (429) |
| Clonality: | Monoclonal |
| Immunogen: | Stromal cell line PA6 |
| Specificity: | NB100-64837 recognises murine vascular adhesion molecule 1 (VCAM-1), a cell surface glycoprotein that is also known as CD106. CD106 is expressed predominantly on endothelial cells and expression is up-regulated during inflammation.The ligand for CD106 is the alpha 4 subunit (CD49d) of the integrin VLA-4 (CD49d/CD29).Clone MVCAM.A(429) is reported to partially block VCAM-1 mediated functions (1).Serotec recommend the use of MCA2297EL for this purpose. |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen, flow cytometry / FACS analysis |
| Localization: | Plasma membrane, Type I membrane protein. |
| Background: | VCAM1 is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the integrins alpha4 beta1 (beta 1 integrin VLA4) and alpha4 beta7 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 is also expressed by several non endothelial cell types including some macrophages, follicular dendritic cells and bone marrow, stromal cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | FACS, IHC-Fr |
| SpeciesSummary: | Mu |
| ALTnames: | anti-CD 106 antibody, anti-CD106 antibody, anti-CD106 Antigen antibody, anti-DKFZp779G2333 antibody, anti-INCAM 100 antibody, anti-L1CAM antibody, anti-MGC99561 antibody, anti-Vascular Cell Adhesion Molecule 1 antibody, anti-Vascular cell adhesion protein 1 antibody, anti-VCAM 1 antibody |
| ProteinTarget: | CD106 |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Kinashi, T. and Springer, T.A. (1994) Adhesion molecules in hematopoietic cells. Blood Cells. 20:25-44. 2. Wormley, F.L. et al. (2001) Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis. Infect. Immun. 69:5072-5079. |
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